4 mL clotted blood in Becton Dickinson (BD) brand red-top vacutainer (labelled 'IGF-1 only')
Minimum blood volume: 4 mL
1 mL clotted blood in BD brand red-top microtainer
Number of vials: 2
Minimum blood volume: 2 mL
(Unit: µg/L)
Age (Year) |
Male |
Female |
< 1 |
16 - 142 |
17 - 185 |
1 - 1.9 |
16 - 134 |
16 - 175 |
2 - 2.9 |
16 - 135 |
16 - 178 |
3 - 3.9 |
30 - 155 |
38 - 214 |
4 - 4.9 |
28 - 181 |
34 - 238 |
5 - 5.9 |
31 - 214 |
37 - 272 |
6 - 6.9 |
38 - 253 |
45 - 316 |
7 - 7.9 |
48 - 298 |
58 - 367 |
8 - 8.9 |
62 - 347 |
76 - 424 |
9 - 9.9 |
80 - 398 |
99 - 483 |
10 - 10.9 |
100 - 449 |
125 - 541 |
11 - 11.9 |
123 - 497 |
152 - 593 |
12 - 12.9 |
146 - 541 |
178 - 636 |
13 - 13.9 |
168 - 576 |
200 - 664 |
14 - 14.9 |
187 - 599 |
214 - 673 |
15 - 15.9 |
201 - 609 |
218 - 659 |
16 - 16.9 |
209 - 602 |
208 - 619 |
17 - 17.9 |
207 - 576 |
185 - 551 |
18 - 19.9 |
108 - 548 |
108 - 548 |
20 - 24.9 |
83 - 456 |
83 - 456 |
25 - 29.9 |
63 - 373 |
63 - 373 |
30 - 39.9 |
53 - 331 |
53 - 331 |
40 - 49.9 |
52 - 328 |
52 - 328 |
50 - 59.9 |
50 - 317 |
50 - 317 |
60 - 69.9 |
41 - 279 |
41 - 279 |
70 - 79.9 |
34 - 245 |
34 - 245 |
80 and above |
34 - 246 |
34 - 246 |
(Source:
Reference interval of IGF-I, LC-MS, was adopted from Quest Diagnostics laboratory report, 2015)
Diagnosis of acromegaly or gigantism.
Evaluation, monitoring and follow-up of growth hormone deficiency or excess in children and adults.
It is important to note that IGF-I levels vary with age and must be interpreted with this in mind. The levels are lower in children and elderly than adults, and show a marked pubertal rise.
Levels are increased in acromegaly, and the test is used in the initial assessment of patients with appropriate symptoms or signs, prior to a growth hormone suppression test. The test may also be of value in monitoring the response to treatment of growth hormone excess. Increased level of IGF-I is also observed in pregnancy.
IGF-I level is reduced in GH deficiency or GH resistance. These conditions result in short stature if acquired in childhood. Reduced level of IGF-I is also observed in patients with anorexia, nutritional deficiency, liver disease and hypothyroidism.